Tyrosine: Benefits, Dosage, Side Effects, Drug Interactions, and Other Important Information


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Tyrosine is a non-essential amino acid that is needed for the production of neurotransmitters, which are vital for proper brain function. It is also a precursor of the neurotransmitters dopamine, adrenaline, and norepinephrine, which control mood, alertness, and stress response. Tyrosine has gained attention for its ability to improve cognitive performance because of its significance in neurological processes, especially when stress and exhaustion are present. This article explores the chemistry of tyrosine as well as its physiological mechanisms, health advantages, ideal dosage, side effects, possible drug interactions, and responsible consumption.

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Tyrosine: Benefits, Dosage, Side Effects, Drug Interactions, and Other Important Information is an original (NootropicsPlanet) article.

Nature of Tyrosine

Tyrosine is required for the synthesis of several neurotransmitters, including adrenaline, norepinephrine, and dopamine. These neurotransmitters affect motivation, mood, and the body’s stress response. They are crucial for brain function. Our body can produce tyrosine naturally from the amino acid phenylalanine. It can also be acquired from diet, particularly from foods high in protein, such as meat, fish, eggs, dairy, nuts, and soy. Tyrosine’s importance in neurological functions has sparked interest in using supplements to improve mental and emotional health.

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Health Benefits of Tyrosine

Tyrosine supplementation offers several potential health benefits, particularly related to cognitive function and stress response:

  1. Improved Cognitive Performance: Supplementation with tyrosine has been shown to improve cognitive flexibility. For example, the ability to switch between thinking about two different concepts, and to enhance working memory during mentally demanding tasks can be improved after tyrosine supplementation. This is particularly evident in situations of sleep deprivation or other stressors that deplete neurotransmitter levels.
  2. Stress Resistance: By supporting the production of dopamine and norepinephrine, tyrosine may help the body cope with stress more effectively. It aids in maintaining cognitive function under pressure, which can be beneficial in high-stress environments or situations.
  3. Mood Regulation: Tyrosine plays a role in the synthesis of dopamine, a neurotransmitter that affects mood. Supplementation may help alleviate symptoms of depression and anxiety, contributing to a more stable mood in susceptible individuals.
  4. Enhanced Alertness: Through its involvement in the production of norepinephrine and epinephrine, tyrosine can increase alertness and vigilance. This may be particularly helpful for people facing fatigue or sleep deprivation.
  5. Supports Metabolism: Tyrosine is a precursor to thyroid hormones, which are critical for regulating metabolism. Adequate levels of tyrosine can therefore support metabolic health and energy levels.
  6. Contributes to Skin Health: Tyrosine is involved in the production of melanin, the pigment responsible for skin and hair color. It may play a role in protecting the skin from harmful UV radiation through melanin synthesis.
Healthy skin.

The Chemistry of Tyrosine

Tyrosine is an amino acid made up of the basic amino acid structure with a phenol group which distinguishes it as a polar amino acid. Its ability to operate as a precursor of essential neurotransmitters and hormones is greatly influenced by this structural characteristic. Tyrosine is produced by the liver, but it can also be consumed through food, such as high-protein foods like fish, poultry, chicken, peanuts, almonds, avocados, bananas, milk, cheese, and soy products.

Physiological Mechanism of Action of Tyrosine

As mentioned, the main mechanism and use of tyrosine is the production of neurotransmitters in the body. Tyrosine is transformed to L-DOPA, which is then turned to dopamine, by the enzyme tyrosine hydroxylase. Norepinephrine and epinephrine can be produced by further metabolizing dopamine. These neurotransmitters play a crucial role in brain activity, affecting mood, thought processes, and the body’s reaction to stress. For example, dopamine plays a key role in the brain’s functions related to motivation, reward, and attention.

The body’s fight-or-flight response, on the other hand, is triggered by norepinephrine and adrenaline, which raise blood pressure, heart rate, and blood sugar levels to get the body ready for action. Tyrosine supplementation may aid in maintaining healthy neurological function by promoting the production of these neurotransmitters, especially under stressful or cognitively demanding situations.

Neurotransmitters function.

Optimal Dosage of Tyrosine

The ideal tyrosine dosage varies according to personal demands and the nature of anticipated benefits. Doses between 150 and 300 mg/kg of body weight have been utilized in studies. These doses were given prior to a stressful event or cognitive task. However, for general supplementation, dosages between 500 mg and 2 grams daily are typically advised. Individual responses to tyrosine can differ, so it’s best to start with a lower dose and monitor your tolerance.

Side Effects of Tyrosine

It is good to also note the effects and your reaction upon supplementation. Certain people may experience nausea, headache, fatigue, and heartburn as side effects of tyrosine supplementation.

Potential Substance Interactions with Tyrosine

Tyrosine may affect the efficacy of thyroid hormone medicines as tyrosine is also a precursor to thyroid hormones. Furthermore, due to its effect on catecholamine neurotransmitter synthesis, tyrosine may interact with drugs that also alter these neurotransmitters, including stimulants, MAO inhibitors, and antidepressants, possibly resulting in negative side effects or decreased therapeutic efficacy.

Healthy thyroid.

Best Practices for Responsible Use

If you are interested in using tyrosine to enhance cognitive performance, adopting a responsible approach is crucial. This involves:

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  1. Starting with a Low Dose: Begin with a lower dose to assess individual tolerance before gradually increasing to the desired dosage.
  2. Monitoring for Side Effects: Pay close attention to any adverse effects that may emerge and adjust the dosage accordingly or discontinue use if necessary.
  3. Consulting a Healthcare Provider: Before starting tyrosine supplementation, particularly for those with pre-existing medical conditions or those taking medication, consulting with a healthcare provider is essential.
  4. Balanced Diet: Ensure adequate intake of tyrosine through a balanced diet rich in proteins, which may reduce the need for supplementation.



There are 20 essential amino acids and tyrosine belongs to the non-essential amino acids. Even though tyrosine can be acquired from food, it may be difficult for busy adults to consume a sufficient amount of tyrosine. This is especially important as tyrosine plays an important part in the production of neurotransmitters such as dopamine and norepinephrine. Hence, tyrosine supplementation is often linked with cognitive support mood regulation, and stress response.

For instance, doses of 150 and 400 mg/kg of body weight tyrosine have been prescribed in research before a stressful event or days that require high cognitive ability which shows positive results. Thus it can be concluded that tyrosine is a good choice if you are looking for a nootropic supplement to improve your well-being and thinking abilities. 

Stress issue.


  1. Tyrosine – Uses, Side Effects, and More. Retrieved from:https://www.webmd.com/vitamins/ai/ingredientmono-1037/tyrosineTyrosine: Benefits, Side Effects and Dosage. Retrieved from: https://www.healthline.com/nutrition/tyrosine
  2. Effect Of Tyrosine Supplementation on Clinical and Healthy Populations Under Stress or Cognitive Demands–A Review. Retrieved from:https://pubmed.ncbi.nlm.nih.gov/26424423/

Behavioral And Cognitive Effects of Tyrosine Intake in Healthy Human Adults. Retrieved from:https://pubmed.ncbi.nlm.nih.gov/25797188/

Important Note: The information contained in this article is for general informational purposes only, and should not be construed as health or medical advice, nor is it intended to diagnose, prevent, treat, or cure any disease or health condition. Before embarking on any diet, fitness regimen, or program of nutritional supplementation, it is advisable to consult your healthcare professional in order to determine its safety and probable efficacy in terms of your individual state of health.

Regarding Nutritional Supplements Or Other Non-Prescription Health Products: If any nutritional supplements or other non-prescription health products are mentioned in the foregoing article, any claims or statements made about them have not been evaluated by the U.S. Food and Drug Administration, and such nutritional supplements or other health products are not intended to diagnose, treat, cure, or prevent any disease.

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