SAMPHIRE: Benefits, Dosage, Side Effects, Drug Interactions, and Other Important Information


Share post:

- Advertisement -

Recently, there has been interest in a possible nootropic supplement called SAMPHIRE (Synthetic Amphiphilic Memory-Enhancing Phospholipid). This article looks into the drug’s chemical makeup, potential interactions with other substances, health advantages, adverse effects, and recommended dosages. Aside it also explores SAMPHIRE’s physiological and neurological effects and aims to offer a guide for anyone considering using SAMPHIRE as a health or nootropic supplement.

You May Also Like:

Battle of the Brain Boosters: Brain MD Omega 3 Power vs. Kori Krill Oil Mind & Body

ONNIT Supplements Antarctic Krill Oil Reviewed: A Leading Memory Support Supplement

SAMPHIRE: Benefits, Dosage, Side Effects, Drug Interactions, and Other Important Information is an original (NootropicsPlanet) article.

Nature of SAMPHIRE

Fundamentally, SAMPHIRE is an artificial substance that is intended to replicate the composition and capabilities of naturally occurring phospholipids, which are vital elements of cell membranes. Phospholipids are essential for the fluidity of cell membranes and are engaged in a number of signaling cascades that support the plasticity and function of the nervous system. Due to SAMPHIRE’s amphiphilic nature, it is able to merge into cell membranes, possibly improving membrane fluidity and improving neuronal communication.

- Advertisement -

Health Benefits of SAMPHIRE

SAMPHIRE is essentially a manufactured material designed to mimic the structure and functions of naturally occurring phospholipids, which are essential components of cell membranes. Phospholipids play a crucial role in several signaling cascades that maintain the nervous system’s flexibility and functionality. They are also necessary for the fluidity of cell membranes.  The following shows SAMPHIRE’s possible health advantages with a focus on cognition:

For Brain and Cognition:

  • Enhanced Cognitive Performance: Improved processing speed, attention, and executive function.
  • Increased Alertness and Focus: Enhanced ability to concentrate on tasks without succumbing to distractions.
  • Improved Neural Efficiency: Better utilization of brain resources during cognitive tasks.

For Memory:

  • Enhanced Memory Formation: Facilitates the encoding of new information.
  • Improved Memory Recall: Easier retrieval of stored information.
  • Strengthened Synaptic Connections: Long-term potentiation, a process vital for long-term memory, is enhanced.

For Mood and Feeling:

  • Mood Stabilization: Reduction in symptoms of anxiety and depression, likely due to the modulation of neurotransmitter systems.
  • Increased Motivation: Elevated dopamine levels contribute to improved motivation and drive.
  • Reduced Mental Fatigue: Enhancements in alertness and cognitive processes can lead to a decrease in mental fatigue.
 Mental Fatigue.

Chemistry of SAMPHIRE

The basis of SAMPHIRE’s chemical structure is two fatty acid chains and a synthetic nootropic moiety joined to a glycerophosphate skeleton. With improved features, this structure is precisely designed to blend in with the phospholipid bilayer of neuronal cell membranes, closely resembling the behavior of naturally occurring phospholipids.

Physiological Mechanism of Action of SAMPHIRE

  1. Integration into Cell Membranes: As mentioned, SAMPHIRE is able to integrate into the cell membranes which increases membrane fluidity. This fluidity is crucial for the proper functioning of proteins and receptors embedded in the cell membrane, directly affecting neuron communication and synaptic plasticity.
  2. Modulation of Neurotransmitter Systems: SAMPHIRE may influence the synthesis, release, and reuptake of key neurotransmitters, such as acetylcholine and dopamine. By enhancing acetylcholine levels, it supports cognitive processes like learning and memory. On the other hand, increased dopamine levels can affect mood, motivation, and focus. As mentioned, SAMPHIRE is able to integrate into the cell membranes which increases membrane fluidity. This fluidity is crucial for the proper functioning of proteins and receptors embedded in the cell membrane, directly affecting neuron communication and synaptic plasticity.
  3. Enhancement of Synaptic Plasticity: By improving membrane fluidity and neurotransmitter availability, SAMPHIRE promotes synaptic plasticity, the brain’s ability to form and reorganize synaptic connections in response to learning and memory.
Neurotransmitter Systems.

Optimal Dosage of SAMPHIRE

Finding the right dosage for SAMPHIRE is essential to maximize its advantages and reduce any possible negative effects. The dose recommendation varies based on an individual’s age, weight, and health status. Nonetheless, clinical trials have indicated a range of dosages that are deemed safe and effective. It is also advised that people start with a low dose and increase it gradually. It is advisable to have regular monitoring by a medical professional to modify the dosage as necessary.

Side Effects of SAMPHIRE

Even though SAMPHIRE is usually well tolerated, some people may have negative side effects, particularly when taking larger doses. Headaches, sleeplessness, and gastrointestinal disorders like nausea and diarrhea are typical adverse effects. The minor side effects usually go away when the supplement is stopped or when the dosage is changed. Users must be aware of these possible reactions and seek immediate medical help if they experience any side effects.

Sleeplessness issue.

Potential Substance Interactions with SAMPHIRE

Like any supplement, SAMPHIRE might have interactions with other drugs, over-the-counter medicines, prescription meds, and herbal supplements. For example, SAMPHIRE’s impact on neurotransmitter systems may conflict with antidepressant or antipsychotic drug effects. Furthermore, because SAMPHIRE alters the makeup of cell membranes, pharmaceuticals that influence blood coagulation, like anticoagulants or antiplatelet medications, may interact with SAMPHIRE as well. To prevent negative interactions, it is imperative that anyone using any other medications or supplements speak with a healthcare provider before beginning SAMPHIRE.

Best Practices for Responsible Use

To ensure the safe and effective use of SAMPHIRE as a nootropic supplement, individuals should adhere to the following best practices:

  1. Consultation with a Healthcare Professional: Before beginning any new supplement regimen, it is advisable to consult with a healthcare provider, particularly for individuals with pre-existing health conditions or those taking other medications.
  2. Adherence to Recommended Dosages: Starting with a low dose and gradually adjusting based on individual tolerance and response is key to finding the optimal dosage that provides cognitive benefits without adverse effects.
  3. Monitoring for Side Effects: Users should be vigilant for any signs of side effects and report them to a healthcare provider. Adjustments to the dosage or discontinuation of the supplement may be necessary based on the severity of side effects.
  4. Awareness of Potential Substance Interactions: Understanding the possible interactions between SAMPHIRE and other substances is critical. Individuals should provide healthcare providers with a comprehensive list of all medications and supplements they are taking to assess the risk of interactions.



There has been an effort to produce a supplement known as SAMPHIRE (Synthetic Amphiphilic Memory-Enhancing Phospholipid). This supplement is produced to closely mimic the structure of natural phospholipids. This property would allow the supplement to be absorbed into part of the cell membrane, thereby improving membrane fluidity and improving neuronal communication. Aside from the structure, SAMPHIRE is also designed to directly influence neurotransmitter activity to support cognitive processes. This supplement is considered safe for consumption. However, professional advice is highly recommended to find the most efficient usage of this supplement. You should also be aware of potential side effects such as headaches, sleeplessness, and other gastrointestinal disorders.



- Advertisement -
  1. Dietary Phospholipids: Role In Cognitive Processes Across the Lifespan. Retrieved from:
  1. Dietary Uridine Enhances the Improvement in Learning and Memory Produced by Administering DHA To Gerbils. Retrieved from:
  1. Effects Of Choline Containing Phospholipids on The Neurovascular Unit: A Review. Retrieved from:

Important Note: The information contained in this article is for general informational purposes only, and should not be construed as health or medical advice, nor is it intended to diagnose, prevent, treat, or cure any disease or health condition. Before embarking on any diet, fitness regimen, or program of nutritional supplementation, it is advisable to consult your healthcare professional in order to determine its safety and probable efficacy in terms of your individual state of health.

Regarding Nutritional Supplements Or Other Non-Prescription Health Products: If any nutritional supplements or other non-prescription health products are mentioned in the foregoing article, any claims or statements made about them have not been evaluated by the U.S. Food and Drug Administration, and such nutritional supplements or other health products are not intended to diagnose, treat, cure, or prevent any disease.

Related articles

Smooth Alder: Benefits, Dosage, Side Effects, Drug Interactions, and Other Important Information

The North American shrub known as smooth alder (alnus serrulata) has recently attracted interest from the nootropic community...

Live Conscious Beyond Brew Mushroom Superfood Coffee: A Review of the Facts About This Leading Energy Product

Beyond Brew Mushroom Superfood Coffee by Live Conscious merges the rich flavor of coffee with the health advantages...

Horbaach Lion’s Mane Mushroom Extract Reviews: A Leading Herbal Nootropic Product

In today's fast-paced world, the demand for optimal brain health has never been higher. With increasing workloads, academic...

Shellac: Benefits, Dosage, Side Effects, Drug Interactions, and Other Important Information

The female lac bug secretes a resin called shellac from trees in the forests of India and Thailand....