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Microdose hallucinogens: an update to “tune in, turn on, drop out”

Hallucinogens (psychedelics) have been studied since the 1960s, and recently, there has been renewed medical interest in their potential therapeutic benefits. Microdosing of lysergic acid diethylamide (LSD) and psilocybin (“Magic Mushrooms”), which are classic serotonergic hallucinogens, is showing potential benefits for mental health.

How they work:

The term psychedelics, derived from Greek, means psyche (“the mind or soul”) and delos (“to show”). Hallucinogens can “alter an individual’s perception and behavior by causing detachment from reality, visual distortions, and other transcendental experiences” ( “Microdosing” involves consuming psychedelic substances at much lower amounts compared to earlier recreational doses.

What they can do:

  • According to, “There is a growing body of evidence suggesting a positive correlation between psychedelic microdosing and improved mental well-being. Users reported positive effects, including improved mood, increased focus, and better daily function.”
  • However, there are concerns, including increased anxiety and physiologic discomfort. Due to the limited scale of the studies conducted so far, the causal relationship between microdosing and mental health improvement remains uncertain.

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