Gamma Oryzanol: Benefits, Dosage, Side Effects, Drug Interactions, and Other Important Information


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Researchers and health-conscious people  are interested in the unusual combination of ferulic acid esters of sterols and triterpene alcohols called gamma oryzanol (GO), which is present in rice bran oil. Even though this nutraceutical is a mainstay of conventional Eastern medicine, its potential therapeutic advantages have sparked  worldwide attention.

Nutritional scientists have been working on transforming GO into  a healthy supplement. This supplement is promotional for  a balanced diet  since it is a potent antioxidant that  treats  dyslipidemia, inflammation, metabolic syndrome, and neuroprotection. The nature, health advantages, recommended dose, potential side effects, drug interactions, and safe use of gamma oryzanol are highlighted  in this article. It will also explain the science underlying the compound’s health-promoting effects, and its unique chemistry and physiological functions.

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Gamma Oryzanol: Benefits, Dosage, Side Effects, Drug Interactions, and Other Important Information is an original (NootropicsPlanet) article.

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Nature of Gamma Oryzanol

Gamma oryzanol (GO), a naturally occurring substance in rice bran oil, is a combination of triterpene alcohols and ferulic acid esters of sterols. GO was initially discovered in rice bran oil, but it is also  found in other grain oils, several fruits, and other vegetables. Due to the wide spectrum of health advantages provided by its special makeup, it is becoming more and more well-liked as a dietary supplement.

Fresh vegetables.

Health Benefits of Gamma Oryzanol

The health advantages of GO have been extensively researched.  As an antioxidant, it can guard against  lipid peroxidation processes, which are linked to many  chronic disorders. Studies further suggest that GO has  benefits that can improve metabolic syndrome, lower inflammation, regulate cholesterol levels, and  neuroprotective properties.

The best use of GO is for treating  dyslipidemia, which is controlled by lowering levels of total cholesterol and LDL while raising levels of HDL. This has been ascribed to its ability to reduce fecal bile acid excretion and prevent cholesterol absorption.

Furthermore, nuclear factor-kappa B (NF-B), a crucial regulator of the inflammatory response, is inhibited by GO, which contributes  to its anti-inflammatory properties.  It has anti-oxidant qualities that scavenge free radicals and lessen oxidative stress, which defends  against cellular harm and chronic illnesses.

 Current research raises the possibility that GO has neuroprotective abilities. Studies on animals have shown that GO decreases oxidative stress in the brain, which enhances  cognition and memory.


Chemistry of Gamma Oryzanol

Ferulic acid esters of phytosterols and triterpene alcohols are the active ingredients in GO. Ferulic acid, a hydroxycinnamic acid, has  powerful antioxidant qualities and  several positive health effects. The lipid-lowering and anti-inflammatory properties of GO  attribute to its sterols and triterpene alcohols.

Physiological Properties of Gamma Oryzanol

The actions of GO’s constituents are principally responsible for its physiological effects. Its interference with mi-cellar stabilization of cholesterol, a crucial stage in intestinal cholesterol absorption, is  the cause of its lipid-lowering impacts. GO efficiently decreases the amount of cholesterol absorbed by the body by blocking this mechanism, decreasing blood cholesterol levels.

The abilityof GO to inhibit the NF-B pathway is what gives it its anti-inflammatory effects. Inflammation  decreases  when this nuclear factor is inhibited, which controls the expression of many inflammatory genes.

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Ferulic acid is responsible for GO’s antioxidant effects since it disarms free radicals and lessens oxidative stress. Its potential for neuroprotection can  reduce oxidative stress.

Optimal Dosage of Gamma Oryzanol

The ideal GO dose depends  on your desired health outcome. Studies have used daily dosages between 300 mg and 600 mg to treat dyslipidemia. The ideal dose for various health advantages still has to be established and will require more research.

Side Effects

GO is often well tolerated and has few documented side effects. Some people could suffer brief bouts of nausea or diarrhea, but these symptoms usually go away on their own.


Substance Interactions

GO can interact with cholesterol-lowering drugs, boosting their effectiveness since  it can decrease cholesterol levels. If you are  taking such drugs, you should use GO cautiously  and under your doctor’s supervision.

Best Responsible Uses of Gamma Oryzanol

The most ethical way to utilize GO as a nutritional supplement is to incorporate it into a healthy diet and way of life. Without first seeing a doctor, it should not be used to substitute any prescription drugs, especially those used to control cholesterol levels.

The potential health advantages of GO are encouraging, but it is  important to use this supplement wisely, taking into account any side effects and  interactions, and to seek professional guidance on the best dosage for achieving various health objectives.

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Gamma Oryzanol:


Due to its distinctive composition of ferulic acid esters of sterols and triterpene alcohols, gamma oryzanol has many health advantages. However, its most noteable property is its ability to lower cholestoral levels in the body. Not only is this a common benefit, but it can also treat insomnia. Its ability to control dyslipidemia, lower inflammation, and  provide neuroprotection make it a desirable dietary supplement.

However, the use of GO should be supported by reliable scientific data and should be done so with a doctor’s approval. To understand the ideal dose completely and the breadth of its health advantages, more study is required. If you have cholestoral issues and are looking for a new supplement to help you manage, talk to your doctor to see if GO is right for you.


  1. “Rice bran oil and gamma-oryzanol in the treatment of hyperlipoproteinaemias and other conditions.” Retrieved from:
  2. “Neuroprotective Effects of Gamma-Oryzanol on the Lipopolysaccharide-Induced Neuroinflammation and Cognitive Impairments in Rats.” Retrieved from:
  3. “Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement.” Retrieved from:

Important Note: The information contained in this article is for general informational purposes only, and should not be construed as health or medical advice, nor is it intended to diagnose, prevent, treat, or cure any disease or health condition. Before embarking on any diet, fitness regimen, or program of nutritional supplementation, it is advisable to consult your healthcare professional in order to determine its safety and probable efficacy in terms of your individual state of health.

Regarding Nutritional Supplements Or Other Non-Prescription Health Products: If any nutritional supplements or other non-prescription health products are mentioned in the foregoing article, any claims or statements made about them have not been evaluated by the U.S. Food and Drug Administration, and such nutritional supplements or other health products are not intended to diagnose, treat, cure, or prevent any disease.

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