Clary Sage: Benefits, Dosage, Side Effects, Drug Interactions, and Other Important Information


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Salvia sclarea, a perennial plant that is native to the Mediterranean Basin, is known for its therapeutic benefits.  As an essential oil, it has attracted a great deal of interest in the health and wellness field. The nature of clary sage, its health advantages, ideal dosage, potential negative effects, possible drug interactions, and suggestions for responsible use as a supplement are all covered in this article.

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Clary Sage: Benefits, Dosage, Side Effects, Drug Interactions, and Other Important Information is an original (NootropicsPlanet) article.

Nature of Clary Sage

The lamiaceae family, which includes clary sage, is distinguished by its tall stems, plush leaves, and delicate white or blue flowers. The chemistry of the plant, especially that of its essential oil, is crucial to its therapeutic uses.

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Clary sage essential oil is made up of a complex mixture of bioactive substances, including volatile terpenes and phenylpropanoids. Linalool, germacrene D, sclareol, and linalyl acetate are a few of the main ingredients. These substances each contain therapeutic qualities.

Monoterpenoids, linalool, and linalool acetate are well known for their calming and soothing properties. Sesquiterpene germacrene D has anti-inflammatory and antimicrobial qualities. A diterpene known as sclareol may have anti-cancer properties. The broad therapeutic potential of clary sage  is influenced by the cumulative synergistic effect of these compounds.

Health Benefits of Clary Sage

Clary sage has a long history of use in traditional medicine and is used for numerous purposes.  Its essential oil in particular has shown to have  potential impacts on the endocrine, nervous, and general health systems.

Nervous System: Because of its potential calming and sedative effects, clary sage essential oil is frequently used in aromatherapy to treat nervous system issues like stress management and anxiety induction. According to research, clary sage oil can lower cortisol levels and have an antidepressant-like effect when inhaled.

 Endocrine System: According to some research, clary sage oil can help maintain hormonal balance. Hot flashes, mood swings, and menstrual cramps are just a few of the symptoms related to menstruation and menopause that have traditionally been treated with it.

General Health: Clary sage has antimicrobial properties that could be helpful in treating minor skin infections. Additionally, it shows anti-inflammatory properties that could reduce discomfort brought on by inflammation.

Health is wealth.

Chemistry of Clary Sage

The scientific name for clary sage is salvia sclarea, and it is a biennial or perennial herb that is a member of the lamiaceae family of mints. The essential oil has a complex mixture of bioactive ingredients that contributes to its therapeutic properties.

Clary sage essential oil’s main chemical components are linalyl acetate, linalool, germacrene D, and sclareol. These substances are a subset of a larger group of chemicals called terpenes, which are aromatic substances that give  plants their distinctive scents.  They frequently have purposes in both conventional and complementary medicine due to their bioactive properties.

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 The monoterpenoids linalool and linalool acetate are recognized for their sedative and calming effects. Sesquiterpenes with anti-inflammatory and antimicrobial properties include germacrene D and sclareol.

Physiological Properties of Clary Sage

Clary sage contains a  combination of bioactive substances that interact with the physiological systems of our bodies and can have strong health benefits.

Nervous System: Clary sage’s calming effects on the nervous system are primarily due to linalyl acetate and linalool. These substances have the ability to bind to receptors in the olfactory bulb upon inhalation, resulting in the transmission of a signal to the limbic system, our  brain’s emotional center. By encouraging feelings of serenity and relaxation, this procedure can lessen stress and anxiety.

 Endocrine System: Clary sage may have an impact on our endocrine system, primarily because of its alleged estrogenic properties. Clary sage contains substances that  mimic the effects of estrogen in the body and help maintain hormonal balance. Menstrual and menopausal symptoms may be lessened by this effect. To support these properties, more scientific data is still  needed.

Skin health and the Immune System: The job of our immune system to combat pathogens. Our immune system can  be strengthened by clary sage’s antimicrobial properties, which are primarily attributed to germacrene D. Clary sage can interact with the skin’s microbiota when applied topically, possibly preventing or treating minor infections.

A girl having healthy skin.

Optimal Dosage of Clary Sage

Whether using dried herb or essential oil, the ideal dosage of clary sage depends on your intended use. A few drops (typically two or three) in a diffuser are frequently sufficient when used in aromatherapy. Clary sage essential oil should always be diluted in a carrier oil prior to use for topical applications. A general rule of thumb is to use a 2% dilution, which is equivalent to about 12 drops of essential oil per ounce of carrier oil.

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The recommended dosage for supplements is frequently stated by the product’s manufacturer. However, because there aren’t enough clinical studies, it’s best to speak with your doctor before beginning clary sage supplementation.

A lady applying the oil drop on face.

Side Effects of Clary Sage

When used properly, clary sage is generally well-tolerated. However, when clary sage oil is applied topically, some people have reported  experiencing skin irritability or allergic reactions. Before a full application, always run a patch test.

Clary sage may have sedative effects, so high doses can make you feel sleepy. As a result, after using clary sage, caution is advised when operating machinery or driving a vehicle.

Clary sage may affect hormonal balance, so pregnant women, nursing mothers, and people with hormone-sensitive conditions should speak with their doctor before using it. 

A boy facing skin discoloration.

Potential Substance Interactions with Clary Sage

Due to its potential calming effects, clary sage may intensify the effects of hypnotic and sedative medications. Because of its potential estrogenic effects, it might also interact with hormone-related medications.Clary sage supplementation requires medical professional advice, especially if you are taking medication or have a chronic health condition.

Responsible Use of Clary Sage

Because of the cooperative actions of its bioactive components, clary sage has a variety of potential health advantages. Responsible use is crucial. It should always be taken at the recommended dosages while taking into account any special health needs you may have. To determine if clary sage is a suitable and secure option for  you and supporting your personal health, consultation with your healthcare professional is imperative.

Clary Sage:


In conclusion, clary sage’s intricate chemistry plays a role in a variety of physiological effects. Scientific research is increasingly confirming its therapeutic potential for the nervous system, endocrine system, immune system, and skin health, demonstrating the adaptable potential of this aromatic herb. Clary sage is a potent medicinal plant with a long history in traditional medicine. Scientific research is increasingly in favor of its wide range of potential health benefits, making it an important natural supplement. To establish its therapeutic applications firmly and grasp its full potential, additional research in clinical trials is required.


  1. Chemistry and Biological Activity of Salvia sclarea. Retrieved from:
  2. Sclareol, a plant diterpene, exhibits potent antiproliferative effects via the induction of apoptosis and mitochondrial membrane potential loss in osteosarcoma cancer cells. Retrieved from:
  3. Clary sage essential oil and its biological activities.Retrieved from:

Important Note: The information contained in this article is for general informational purposes only, and should not be construed as health or medical advice, nor is it intended to diagnose, prevent, treat, or cure any disease or health condition. Before embarking on any diet, fitness regimen, or program of nutritional supplementation, it is advisable to consult your healthcare professional in order to determine its safety and probable efficacy in terms of your individual state of health.

Regarding Nutritional Supplements Or Other Non-Prescription Health Products: If any nutritional supplements or other non-prescription health products are mentioned in the foregoing article, any claims or statements made about them have not been evaluated by the U.S. Food and Drug Administration, and such nutritional supplements or other health products are not intended to diagnose, treat, cure, or prevent any disease.

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