Caralluma: Benefits, Dosage, Side Effects, Drug Interactions, and Other Important Information


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Caralluma is a genus of flowering plants in the Apocynaceae family that is mostly cultivated in countries such as Saudi Arabia and India, as well as geographical areas like Northern Africa, and Southern Europe. One of the most researched species, Caralluma fimbriata, has historically been consumed to reduce hunger, relieve thirst, and increase stamina. Its medicinal and health advantages have sparked an increase in research by nutritional scientists on its phytochemistry and physiological effects, which this article will elaborate upon.

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Nature of Caralluma

Succulent plants of the genus Caralluma are members of the Apocynaceae family. This genus has more than a hundred species, but Caralluma fimbriata, a cactus-like plant, is the one species from this genus and family that has been most often investigated for its health advantages.

This plant has a long history of usage in traditional medical systems, especially in India.  Through various points in history and location, Indian people have consumed this plant, often eaten as a vegetable, used to make pickles and other preserves, in addition to being employed in Ayurvedic (a natural system of medicine) treatment. When embarking on a long day of hunting, some inhabitants of rural India have also eaten Caralluma fimbriata to sustain them during times of famine and used it as an appetite suppressor.

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Caralluma fimbriata possesses a high concentration of bioactive substances like flavone glycosides, pregnane glycosides, bitter principles, and megastigmanes, according to phytochemical study. Pregnane glycosides are the main bioactive components of Caralluma fimbriata that to which its health advantages can be owed.

Fresh vegetables.

Health Benefits of Caralluma

A great deal of the research conducted on this plant has to do with its abilities to suppress appetite and help people control their weight. The pregnane glycosides contained within Caralluma fimbriata interact with the hypothalamus, which is the brain’s center for controlling hunger.  This interaction between this component of the plant and the human brain successfully reduces the appetite. A randomized clinical experiment that used Caralluma extract as a dietary supplement for participants found that it dramatically decreased their food intake and appetites, consequently leading to weight reduction.

In the past, hunters and warriors in the parts of the world where this plant flourishes would consume Caralluma to increase their stamina during extended and/or strenuous activity. The plant has the capacity to speed up the human body’s fat oxidation processes.  As a result, users experience increased stamina, making Caralluma fimbriata an effective energy source during extended physical effort.

A lady is doing exercise.

Chemistry of Caralluma

Numerous phytochemicals, including flavone glycosides, bitter principles, saponins, pregnane glycosides, and numerous kinds of megastigmanes, are present in Caralluma fimbriata. Pregnane glycosides, notably Bouceroside I, Bouceroside II, and Bouceroside VI, are the main bioactive components. These phytochemical components support its therapeutic potential and serve as the main pharmacological foundation for its many health advantages.

Physiological Mechanisms of Action of Caralluma

Caralluma fimbriata’s physiological mechanisms of action are primarily focused on its function as an appetite suppressant and possible anti-obesity drug. It is thought that the pregnane glycosides in this plant inhibit the function of many enzymes involved in the creation of new fat, causing the body to break down its stored fat stores.

  1. Suppression of Appetite: Pregnane glycosides in Caralluma fimbriata interact with the brain’s hypothalamus, which regulates hunger and appetite. Consumers of the plant, as a result, experience a heightened perception of fullness as a consequence of this interaction leading to a decrease in total, daily food intake and aiding in weight control.
  2. Fat Synthesis Inhibition: According to studies, Caralluma fimbriata extract reduces the activity of enzymes that produce fat, including Acetyl CoA Carboxylase (ACC) and Fatty Acid Synthase (FAS). Caralluma blocks the growth of new fat cells by blocking these enzymes, causing the body to burn its stored fat for energy instead.
  3. Improvement of Fat Oxidation: There is some evidence that Caralluma fimbriata may improve how the body burns fat. With regular consumption, the body utilises fat that has been stored as an energy source, aiding in weight control, and maybe boosting endurance during physical activity.

Therefore, the physiological mechanisms of action of Caralluma fimbriata constitute a multi-targeted strategy in hunger control and weight loss promotion. It is a potential, natural weight-loss treatment because of its distinct method of action, long history of use, and safety record. But in order to properly understand these pathways and their consequences for human health, more exacting clinical studies are required.


Optimal Dosage of Caralluma

Usually, taking a single or two split dosages of 500 to 1,000 mg per day are advised. A daily dose of 1,000 mg resulted in a considerable reduction in weight and shrinkage of the waist circumference in a 60-day randomized, double-blind, placebo-controlled research study. However, please think about when you can regularly take a dose, as the time of consumption should be customized. Ideally, you should eat the supplement around 30 minutes before eating each meal to benefit from its appetite-suppressing qualities.

Side Effects of Caralluma

Caralluma has a lot of health advantages, but you may potentially have some side effects—usually minimal and brief. Mild gastrointestinal issues can occur, including constipation, stomach discomfort, and gas, which are often mentioned as adverse effects. Although some people may briefly suffer a rise in heart rate or blood pressure, these symptoms often dissipate on their own. Individual tolerance and reaction to Caralluma varies, as with ingestion or consumption of any dietary supplement; thus, if you choose to use this supplement, please be cautious as your starting doses should be prudent and progressively increase over time.

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A lady having pain in her belly.

Potential Substance Interactions

There are no serious known interactions between Caralluma and other drugs as of the most recent literature. The effects of appetite suppressants and diabetes drugs, however, may potentially be enhanced by it because of its influence on appetite and glucose metabolism. Therefore, before beginning Caralluma supplements, those of you who are utilizing these drugs should speak with a healthcare professional.


Best Practices for Responsible Use

Caralluma fimbriata works best as a dietary supplement for controlling weight. To recap, based on what is known at this time in science, the following recommendations for use are provided:

  1. Appetite Suppression: Caralluma may assist with appetite suppression, calorie intake reduction, and weight control by taking you take it roughly 30 minutes before meals.
  2. Energy and Endurance: Caralluma has historically been used to boost energy levels and endurance during physical exercise like hunting. Early investigations show Caralluma may increase the body’s oxidation, offering an effective energy source for sustained effort, even if there is little current scientific evidence to support this.
  3. Dose: For supplementing with Caralluma, a normal dose ranges from 500 to 1,000 mg per day. You should always start at the lower end of this range to assess tolerance and make necessary adjustments.
  4. Consistency: As with other dietary supplements, Caralluma must be used consistently for maximum benefits. Nevertheless, even if you don’t instantly see the intended benefits, always follow the dose guidelines and refrain from going over the allowed amount.
  5. Health Monitoring: If you already have a medical issue or are using other drugs, you should only take Caralluma supplements with a doctor’s advice. To ensure safe and efficient usage, the healthcare professional may assist with the monitoring of health indicators and dose adjustments as necessary.

Keep in mind that although Caralluma may help your with weight control behaviors, it should only be taken as a component of a complete program that also includes other healthy lifestyle choices like a nutritious diet and frequent exercise. It is a tool that may encourage good behaviors and lifestyle improvements rather than a miraculous cure.



Caralluma fimbriata is a cactus-like plant that, with responsible consumption, is a supplement that can help you suppress your appetite, increase your physical endurance, and reduce your waist size.  Please be aware that for greatest efficacy, consistently take a prescribed 500 – 1,000 mg dose 30 minutes before having a meal.  Caralluma fimbriata can be added to your new or existing series of lifestyle changes that target weight control.  Stay tuned for more research and investigation into its health advantages and benefits.


  1. Efficacy and tolerability of a novel herbal formulation for weight management in obese subjects: a randomized double-blind placebo-controlled clinical study. Retrieved from:
  2. The effect of an orally-dosed Caralluma Fimbriata extract on appetite control and body composition in overweight adults. Retrieved from:
  3. The use of Caralluma fimbriata as an appetite suppressant and weight loss supplement: a systematic review and meta-analysis of clinical trials. Retrieved from:

Important Note: The information contained in this article is for general informational purposes only, and should not be construed as health or medical advice, nor is it intended to diagnose, prevent, treat, or cure any disease or health condition. Before embarking on any diet, fitness regimen, or program of nutritional supplementation, it is advisable to consult your healthcare professional in order to determine its safety and probable efficacy in terms of your individual state of health.

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Regarding Nutritional Supplements Or Other Non-Prescription Health Products: If any nutritional supplements or other non-prescription health products are mentioned in the foregoing article, any claims or statements made about them have not been evaluated by the U.S. Food and Drug Administration, and such nutritional supplements or other health products are not intended to diagnose, treat, cure, or prevent any disease.

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